Kognitive Leistungssteigerung 2 min read

Selank

META-TITLE: [TODO: Selank — Anxiolytic Peptide Research Profile | Brand]
META-DESC: [TODO: Selank research overview — tuftsin analog, anxiolytic without sedation, GABA/serotonin modulation, immune peptide.]

[TODO] Hook — Selank as a synthetic tuftsin analog, anxiolytic without sedation or dependence, dual cognitive/immune mechanism, prescribed in Russia

[IMAGE: Selank molecular structure — Thr-Lys-Pro-Arg-Pro-Gly-Pro heptapeptide]

What is Selank?

[TODO] Full name — Selank, Thr-Lys-Pro-Arg-Pro-Gly-Pro (tuftsin + PGP)
[TODO] Origin — Institute of Molecular Genetics, Russian Academy of Sciences
[TODO] Base peptide — synthetic analog of tuftsin (natural immune peptide)
[TODO] Approved use — Russia (generalized anxiety disorder, neurasthenia)
[TODO] Administration — intranasal (primary)

Mechanism of Action

[TODO] GABAergic — allosteric modulation of GABA-A receptors (benzodiazepine-like but without sedation)
[TODO] Serotonin — modulates 5-HT metabolism, increases serotonin availability
[TODO] Enkephalins — stabilizes enkephalin degradation, endogenous opioid pathway
[TODO] BDNF — increases expression (shared with Semax)
[TODO] Immune — tuftsin backbone, IL-6 modulation, NK cell activation

Research Highlights

[TODO] Anxiety — equivalent to benzodiazepines in Russian clinical trials, without sedation/addiction
[TODO] Cognitive — improved memory under stress, attention enhancement
[TODO] Immune — enhanced immune function via tuftsin-mediated phagocyte activation
[TODO] Gene expression — modulates 45 genes related to neurotransmission
[TODO] No tolerance — no dependence or withdrawal observed in studies

Dosing Protocols (Research Context)

[TODO] Intranasal — 250-500mcg/day (1-3 drops per nostril, 2-3x daily)
[TODO] Subcutaneous — 100-300mcg/day
[TODO] N-Acetyl Selank — enhanced variant with improved stability
[TODO] Duration — 14-21 day protocols typical

Safety & Considerations

[TODO] No sedation, addiction, or cognitive impairment (key advantage over benzodiazepines)
[TODO] No withdrawal — can be discontinued abruptly
[TODO] Side effects — minimal; occasional mild nasal irritation
[TODO] Western data — limited clinical data outside Russian literature